Certified Nephrology Nurse Exam Practice 2025 – Complete Study Guide

Tacrolimus is a cornerstone immunosuppressive agent frequently utilized in kidney transplant patients due to its potent efficacy in preventing organ rejection. It functions by inhibiting T-lymphocyte activation and proliferation, which are critical processes in the immune response that could lead to the rejection of the transplanted kidney.

Tacrolimus is typically prescribed as part of a combination therapy alongside corticosteroids and other immunosuppressants, creating a robust regimen designed to minimize the risks of both acute and chronic rejection. Its use has been associated with improved graft survival rates when compared to some older agents.

While cyclosporine is another immunosuppressant commonly used in transplant settings, tacrolimus has largely become the preferred choice because it has a more favorable pharmacokinetic profile, which allows for less frequent dosing and better management of drug levels in patients.

Sirolimus and azathioprine also play roles in immunosuppression; however, they are used in different contexts or as adjuncts in some cases. Sirolimus, for example, is used for its ability to inhibit cell division and has nephroprotective properties but can lead to different side effects and complications when used solely for kidney transplant patients. Azathioprine is an older